E2387
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E2387
Sigma
5′-(N-Ethylcarboxamido)adenosine
powder
| Synonym: | NECA |
| CAS Number: | 35920-39-9 |
| Linear Formula: | C12H16N6O4 |
| Molecular Weight: | 308.29 |
| MDL number: | MFCD00069195 |
| PubChem Substance ID: | 24277684 |
Description
| Biochem/physiol Actions | Potent adenosine receptor agonist with nearly equal affinity at A1 and A2 receptors. |
Properties
| form | powder |
| color | white |
| solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL Solutions may be stored for several days at 4 °C. |
| DMSO: 14 mg/mL Solutions may be stored for several days at 4 °C. | |
| 0.1 M HCl: 3.4 mg/mL Solutions may be stored for several days at 4 °C. | |
| H2O: insoluble | |
| ethanol: Solutions may be stored for several days at 4 °C.soluble | |
| Gene Information | human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140) |
| rat ... Adora1(29290), Adora2a(25369), Adora2b(29316), Adora3(25370) | |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T+ |
| Risk Statements | 28 |
| Safety Statements | 22-26-36-45 |
| RIDADR | UN2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | VJ2232000 |
References
| reference | Williams, Adenosine-a selective neuromodulator in the mammalian CNS?. Trends Neurosci. 7, 1, (1984) |
| Cusack, et al., 5'-N-Ethylcarboxamidoadenosine - a potent inhibitor of human platelet aggregation. Br. J. Pharmacol. 72, 443, (1981) Abstract | |
| Bruns, et al., Characterization of the A2 adenosine receptor labeled by [3H]-NECA in rat striatal membranes.,. Mol. Pharmacol. 29, 331, (1986) Abstract |
